| Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level | |
| Liu, Zixuan; Xia, Xiaomin; Lv, Xuying; Song, Erqun; Song, Yang | |
| 2021-12-15 | |
| Source Publication | ENVIRONMENTAL POLLUTION
 |
| ISSN | 0304-3894 |
| Volume | 420Pages:- |
| Abstract | Coagulation is well-established for controlling regulated disinfection by-products (DBPs), but its effectiveness for controlling unregulated DBPs remains unclear. The efficiency of coagulation in controlling unregulated DBPs requires clarification owing to their relatively high toxicity. In this study, three Al-based coagulants, aluminum sulfate (Alum), polyaluminum chloride (PAC), and a novel type of covalently bond hybrid coagulant (CBC, synthesized using AlCl3) were selected, and the coagulation performance of these Al-based coagulants in controlling DBPs and DBP-associated toxicity was compared over 5 classes of DBPs, including trihalomethanes, haloacetic acids, haloacetaldehydes, haloacetonitriles, and halonitromethanes. The results showed that Alum was the least efficient in removing DBP precursors among the three coagulants. The effectiveness of CBC and PAC for DBP control varied with the characteristics of source waters. CBC had an advantage in water with a low content of humic acids, and reduced DBP concentration and DBP-associated toxicity by 47% and 25%, respectively. For water rich in aromatic organics, CBC might serve as DBP precursors at a high-required dosage, suggesting that a trade-off between enhanced DBP control and serving as DBP precursors should be considered for CBC coagulation; PAC achieved the most reduction in DBP concentration and DBP-associated toxicity by 50% and 34%, respectively. |
| Department | 环境化学与生态毒理学国家重点实验室 |
| Keyword | Disinfection by-products Precursor Coagulation Al-based coagulants Covalently bond hybrid coagulant |
| Document Type | 期刊论文 |
| Identifier | https://ir.rcees.ac.cn/handle/311016/46807 |
| Collection | 环境化学与生态毒理学国家重点实验室 |
| Affiliation | 1.Southwest Univ, Coll Pharmaceut Sci, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, Chongqing 400715, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, 18 Shuangqing Rd, Beijing 100085, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Zixuan,Xia, Xiaomin,Lv, Xuying,et al. Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level[J]. ENVIRONMENTAL POLLUTION,2021,420:-. |
| APA | Liu, Zixuan,Xia, Xiaomin,Lv, Xuying,Song, Erqun,&Song, Yang.(2021).Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level.ENVIRONMENTAL POLLUTION,420,-. |
| MLA | Liu, Zixuan,et al."Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level".ENVIRONMENTAL POLLUTION 420(2021):-. |
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| Iron-bearing nanopar（7563KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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