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Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level
Liu, Zixuan; Xia, Xiaomin; Lv, Xuying; Song, Erqun; Song, Yang
2021-12-15
Source PublicationENVIRONMENTAL POLLUTION
ISSN0304-3894
Volume420Pages:-
AbstractCoagulation is well-established for controlling regulated disinfection by-products (DBPs), but its effectiveness for controlling unregulated DBPs remains unclear. The efficiency of coagulation in controlling unregulated DBPs requires clarification owing to their relatively high toxicity. In this study, three Al-based coagulants, aluminum sulfate (Alum), polyaluminum chloride (PAC), and a novel type of covalently bond hybrid coagulant (CBC, synthesized using AlCl3) were selected, and the coagulation performance of these Al-based coagulants in controlling DBPs and DBP-associated toxicity was compared over 5 classes of DBPs, including trihalomethanes, haloacetic acids, haloacetaldehydes, haloacetonitriles, and halonitromethanes. The results showed that Alum was the least efficient in removing DBP precursors among the three coagulants. The effectiveness of CBC and PAC for DBP control varied with the characteristics of source waters. CBC had an advantage in water with a low content of humic acids, and reduced DBP concentration and DBP-associated toxicity by 47% and 25%, respectively. For water rich in aromatic organics, CBC might serve as DBP precursors at a high-required dosage, suggesting that a trade-off between enhanced DBP control and serving as DBP precursors should be considered for CBC coagulation; PAC achieved the most reduction in DBP concentration and DBP-associated toxicity by 50% and 34%, respectively.
Department环境化学与生态毒理学国家重点实验室
KeywordDisinfection by-products Precursor Coagulation Al-based coagulants Covalently bond hybrid coagulant
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/46807
Collection环境化学与生态毒理学国家重点实验室
Affiliation1.Southwest Univ, Coll Pharmaceut Sci, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, Chongqing 400715, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, 18 Shuangqing Rd, Beijing 100085, Peoples R China
Recommended Citation
GB/T 7714
Liu, Zixuan,Xia, Xiaomin,Lv, Xuying,et al. Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level[J]. ENVIRONMENTAL POLLUTION,2021,420:-.
APA Liu, Zixuan,Xia, Xiaomin,Lv, Xuying,Song, Erqun,&Song, Yang.(2021).Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level.ENVIRONMENTAL POLLUTION,420,-.
MLA Liu, Zixuan,et al."Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level".ENVIRONMENTAL POLLUTION 420(2021):-.
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