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Nucleophilic and redox properties of polybrominated diphenyl ether derived-quinone/hydroquinone metabolites are responsible for their neurotoxicity
Xu, Lei; Wang, Yuting; Song, Erqun; Song, Yang
2021-12-15
Source PublicationJOURNAL OF HAZARDOUS MATERIALS
ISSN0956-053X
Volume136Pages:122-131
AbstractIt is unadvisable to discuss the antibiotic resistance genes (ARGs) reduction in anaerobic digestion (AD) system neglecting its main purpose-methane production. The methane production improvement coupling with antibiotic resistance genes (ARGs) reduction in anaerobic digestion (AD) by zero valent iron (ZVI) were simultaneously investigated. Whether the role of ZVI on the ARGs fate was random or specific was clarified through the highthroughput qPCR (HT-qPCR). Results indicated that ZVI improved methane production and ARGs reduction by 23.9% and 25.0%, respectively. The improved methane production was associated with chemical reaction and variances of microbial community caused by ZVI, where DIET between Petrimonas, Clostridium and Syntrophomonas, Methanosarcina was established along with ACAS being enriched. ZVI specifically, not randomly, facilitated the reduction of aminoglycoside resistance genes of antibiotic inactivation and tetracycline resistance genes of ribosomal protection proteins. The specifical reduction could be attributed to enzyme activity inhibition and intracellular ionic disturbance caused by higher amounts of ZVI, although most of ARGs fate could be well explained by microbial community which contributed the most to ARGs dynamics as a whole. ZVI-based AD was a promising way for the improvement of methane production coupling ARGs reduction.
Department环境化学与生态毒理学国家重点实验室
KeywordZero valent iron Anaerobic digestion Antibiotic resistance genes High-throughput qPCR Swine manure
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/46817
Collection环境化学与生态毒理学国家重点实验室
Affiliation1.Southwest Univ, Coll Pharmaceut Sci, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, 2 Tiansheng Rd, Chongqing 400715, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, 18 Shuangqing Rd, Beijing 100085, Peoples R China
Recommended Citation
GB/T 7714
Xu, Lei,Wang, Yuting,Song, Erqun,et al. Nucleophilic and redox properties of polybrominated diphenyl ether derived-quinone/hydroquinone metabolites are responsible for their neurotoxicity[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,136:122-131.
APA Xu, Lei,Wang, Yuting,Song, Erqun,&Song, Yang.(2021).Nucleophilic and redox properties of polybrominated diphenyl ether derived-quinone/hydroquinone metabolites are responsible for their neurotoxicity.JOURNAL OF HAZARDOUS MATERIALS,136,122-131.
MLA Xu, Lei,et al."Nucleophilic and redox properties of polybrominated diphenyl ether derived-quinone/hydroquinone metabolites are responsible for their neurotoxicity".JOURNAL OF HAZARDOUS MATERIALS 136(2021):122-131.
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