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The effect of anthropogenic activities on the environmental fate of chlorinated paraffins in surface soil in an urbanized zone of northern China
Li, Feifei; Shi, Rongguang; Wang, Yingjun; He, Anen; Han, Ziming; Zheng, Xiangqun; Li, Chang; Gao, Wei; Wang, Yawei; Jiang, Guibin
2021-11-01
Source PublicationENVIRONMENTAL POLLUTION
ISSN1944-8244
Volume13Issue:43Pages:50823-50835
AbstractEndosome capture is a major physiological barrier to the successful delivery of nanomedicine. Here, we found a strategy to deliver ultrasmall nanoparticles (<10 nm) to the cytosolic compartment of pyroptotic cells with spontaneous endosomal escape. To mimic pathological pyroptotic cells, J774A.1 macrophages were stimulated with lipopolysaccharide (LPS) plus nigericin (Nig) or adenosine triphosphate (ATP) to form specific gasdermin D protein-driven membrane pores at an N-terminal domain (GSDMD(Nterm)). Through GSDMD(Nterm) membrane pores, both anionic and cationic nanoparticles (NPs) with diameters less than 10 nm were accessed into the cytosolic compartment of pyroptotic cells in an energyand receptor-independent manner, while NPs larger than the size of GSDMD(Nterm) membrane pores failed to enter pyroptotic cells. NPs pass through GSDMD(Nterm) membrane pores via free diffusion and then access into the cytoplasm of pyroptotic cells in a microtubule-independent manner. Interestingly, we found that LPS-primed NPs may act as Trojan horse, deliver extracellular LPS into normal cells through endocytosis, and in turn induce GSDMD(Nterm) membrane pores, which facilitate further internalization of NPs. This study presented a straightforward method of distinguishing normal and pyroptotic cells through GSDMD membrane pores, implicating their potential application in monitoring the delivery of desired nanomedicines in pyroptosis-related diseases and conditions.
Department环境化学与生态毒理学国家重点实验室
Keywordnanoparticles pyroptosis endocytosis GSDMD membrane pores
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/46828
Collection环境化学与生态毒理学国家重点实验室
Affiliation1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, POB 2871, Beijing 100085, Peoples R China
2.Minist Agr & Rural Affairs, Agroenvironm Protect Inst, Tianjin 300191, Peoples R China
3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Environm, Hangzhou 310000, Peoples R China
5.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Aquat Chem, Beijing 100085, Peoples R China
Recommended Citation
GB/T 7714
Li, Feifei,Shi, Rongguang,Wang, Yingjun,et al. The effect of anthropogenic activities on the environmental fate of chlorinated paraffins in surface soil in an urbanized zone of northern China[J]. ENVIRONMENTAL POLLUTION,2021,13(43):50823-50835.
APA Li, Feifei.,Shi, Rongguang.,Wang, Yingjun.,He, Anen.,Han, Ziming.,...&Jiang, Guibin.(2021).The effect of anthropogenic activities on the environmental fate of chlorinated paraffins in surface soil in an urbanized zone of northern China.ENVIRONMENTAL POLLUTION,13(43),50823-50835.
MLA Li, Feifei,et al."The effect of anthropogenic activities on the environmental fate of chlorinated paraffins in surface soil in an urbanized zone of northern China".ENVIRONMENTAL POLLUTION 13.43(2021):50823-50835.
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