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Characterization of nanoparticles using coupled gel immobilization and label-free optical imaging
Wang, Fengbang; Chen, Zihan; Wang, Yuanyuan; Yin, Yongguang; Ma, Chunyan; Song, Maoyong; Jiang, Guibin
2021-10-03
Source PublicationCHEMICAL COMMUNICATIONS
ISSN0039-9140
Volume235Pages:-
AbstractA thermal desorption associative ionization time-of-flight mass spectrometer was developed for ultrasensitive detection of semi-volatile chemical warfare agents (CWAs). The excited-state CH2Cl2-induced associative ionization method presented a soft ionization characterization and an excellent sensitivity towards CWAs. The detection sensitivities of the investigated nine CWA-related substances were 2.56 x 10(5)-5.01 x 10(6) counts ng(-1) in a detection cycle (30 s or 100 s). The corresponding 3 sigma limits of detection (LODs) were 0.08-3.90 pg. Compared with the best-documented LODs via the dielectric barrier discharge ionization (DBDI) and secondary electrospray ionization (SESI), the obtained LODs of the investigated compounds were improved by 2-76 times. Additionally, the measured sensitivity of 2-Chloroethyl ethyl, a proxy for mustard gas, is 550 counts pptv(-1), which exceeds the DBDI and SESI's corresponding values (4.4 counts pptv(-1) and 6.5 counts pptv(-1)) nearly by two orders of magnitude. A field application simulation was conducted by putting a strip of PTFE film contaminated with the CWA-related agent into the thermal desorption unit. The simulation showed that the sensitivities of the instrument via swipe surveying could achieve 2.19 x 10(5) to 5.23 x 10(6) counts ng(-)(1). The experimental results demonstrate that the excited-state CH2Cl2-induced associative ionization is an ultrasensitive ionization method for CWAs and reveal a prospect for improving the detection of CWA species future.
Department环境纳米技术与健康效应重点实验室
KeywordChemical warfare agents Organophosphorus pesticides Chemical ionization Excited-state CH2Cl2-induced associative ionization Mass spectrometry Field application
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/46833
Collection环境纳米技术与健康效应重点实验室
Affiliation1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Nanotechnol & Hlth Effects, Beijing 100085, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Ctr Dis Control & Prevent, Natl Inst Environm Hlth, China CDC Key Lab Environm & Populat Hlth, Beijing 100050, Peoples R China
4.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China
Recommended Citation
GB/T 7714
Wang, Fengbang,Chen, Zihan,Wang, Yuanyuan,et al. Characterization of nanoparticles using coupled gel immobilization and label-free optical imaging[J]. CHEMICAL COMMUNICATIONS,2021,235:-.
APA Wang, Fengbang.,Chen, Zihan.,Wang, Yuanyuan.,Yin, Yongguang.,Ma, Chunyan.,...&Jiang, Guibin.(2021).Characterization of nanoparticles using coupled gel immobilization and label-free optical imaging.CHEMICAL COMMUNICATIONS,235,-.
MLA Wang, Fengbang,et al."Characterization of nanoparticles using coupled gel immobilization and label-free optical imaging".CHEMICAL COMMUNICATIONS 235(2021):-.
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