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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of immunity in THP-1-derived macrophages and the possible mechanisms
Li, Xinyan; Li, Na; Han, Yingnan; Rao, Kaifeng; Ji, Xiaoya; Ma, Mei
2021-12-15
Source PublicationENVIRONMENTAL POLLUTION
ISSN0048-9697
Volume791Pages:-
AbstractThis study aimed to explore the effect of temperature on the persistence of fecal bacteria by multiple approaches in ambient anaerobic digestion systems treating swine manure. Both lab-scale (15 degrees C, 20 degrees C, and 25 degrees C) and field (26 degrees C on average) studies were conducted by high-throughput sequencing and culture-based methods. A community-wide Bayesian SourceTracker method was used to identify and estimate the fecal bacterial proportion in anaerobic effluent. High proportional contributions of fecal bacteria were observed in effluent at 15 degrees C (73%) and 20 degrees C (75%), while less was found at 25 degrees C (19%). This was further verified by a field study (23%) and an anaerobic reactor study at 37 degrees C (0.01%). To explore the potential reasons for differences in fecal bacterial proportions, bacterial taxa were divided into lost and survivor taxa in manure waste by LEfSe. The survivor taxa abundance was positively correlated with SourceTracker proportion (r = 0.913, P = 0.001), but negatively correlated with temperature (r = -0.826, P = 0.006). In addition, biomarkers in effluent were divided into enriched and de novo taxa. Enriched taxa, including acidogenic and acetogenic bacteria, were found at all temperatures, whereas taxa related to organic degradation were multiplied de novo at 25 degrees C. Variation partition analysis showed that temperature could explain 30% of variations in effluent bacterial community. Moreover, coliforms isolated from the manure and effluents at 15 degrees C and 20 degrees C were also phylogenetically related. This study provided comprehensive insight into the impact of temperature on the persistence of fecal bacteria in anaerobic effluent, with temperatures over 25 degrees C recommended to reduce fecal pollution. (c) 2021 Elsevier B.V. All rights reserved.
Department中国科学院饮用水科学与技术重点实验室
KeywordFecal pollution Animal manure waste treatment Ambient anaerobic digestion SourceTracker Bacterial community structure
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/46903
Collection中国科学院饮用水科学与技术重点实验室
Affiliation1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Drinking Water Sci & Technol, Shuangqing Rd 18, Beijing 100085, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Xinyan,Li, Na,Han, Yingnan,et al. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of immunity in THP-1-derived macrophages and the possible mechanisms[J]. ENVIRONMENTAL POLLUTION,2021,791:-.
APA Li, Xinyan,Li, Na,Han, Yingnan,Rao, Kaifeng,Ji, Xiaoya,&Ma, Mei.(2021).2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of immunity in THP-1-derived macrophages and the possible mechanisms.ENVIRONMENTAL POLLUTION,791,-.
MLA Li, Xinyan,et al."2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of immunity in THP-1-derived macrophages and the possible mechanisms".ENVIRONMENTAL POLLUTION 791(2021):-.
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