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A Critical Review on Transplacental Transfer of Per- and Polyfluoroalkyl Substances: Prenatal Exposure Levels, Characteristics, and Mechanisms
Donghui Ma, Yao Lu, Yong Liang, Ting Ruan, Juan Li, Chunyan Zhao,* Yawei Wang,* and Guibin Jiang
2021
Source PublicationEnvironmental Science & Technology
Issue0Pages:1-13
Abstract

Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances (PFASs) has aroused public concerns as it can pose multiple health threats to pregnant women and cause adverse birth outcomes for fetuses. In previous studies, the prenatal exposure levels and transplacental transfer efficiencies (TTE) of PFASs have been reported and discussed. Specifically, the binding affinities between PFASs and some transporters were determined, demonstrating that the TTE values of PFASs are highly dependent on their binding behaviors. To summarize primary findings of previous studies and propose potential guidance for future research, this article provides a systematic overview on levels and characteristics of prenatal exposure to PFASs worldwide, summarizes relationships between TTE values and structures of PFASs, and discusses possible transplacental transfer mechanisms, especially for the combination between PFASs and transporters. Given the critical roles of transporters in the transplacental transfer of PFASs, we conducted molecular docking to further clarify the binding behaviors between PFASs and the selected transporters. We proposed that the machine learning can be a superior method to predict and reveal behaviors and mechanisms of the transplacental transfer of PFASs. In total, this is the first review providing a comprehensive overview on the prenatal exposure levels and transplacental transfer mechanisms of PFASs.

KeywordPerfluoroalkyl And Polyfluoroalkyl Substances, Prenatal Exposure, Transplacental Transfer, Molecular Docking, Quantitative Structure−activity Relationship
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/46961
Collection环境化学与生态毒理学国家重点实验室
Recommended Citation
GB/T 7714
Donghui Ma, Yao Lu, Yong Liang, Ting Ruan, Juan Li, Chunyan Zhao,* Yawei Wang,* and Guibin Jiang. A Critical Review on Transplacental Transfer of Per- and Polyfluoroalkyl Substances: Prenatal Exposure Levels, Characteristics, and Mechanisms[J]. Environmental Science & Technology,2021(0):1-13.
APA Donghui Ma, Yao Lu, Yong Liang, Ting Ruan, Juan Li, Chunyan Zhao,* Yawei Wang,* and Guibin Jiang.(2021).A Critical Review on Transplacental Transfer of Per- and Polyfluoroalkyl Substances: Prenatal Exposure Levels, Characteristics, and Mechanisms.Environmental Science & Technology(0),1-13.
MLA Donghui Ma, Yao Lu, Yong Liang, Ting Ruan, Juan Li, Chunyan Zhao,* Yawei Wang,* and Guibin Jiang."A Critical Review on Transplacental Transfer of Per- and Polyfluoroalkyl Substances: Prenatal Exposure Levels, Characteristics, and Mechanisms".Environmental Science & Technology .0(2021):1-13.
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