| A short review of human exposure to antibiotics based on urinary biomonitoring | |
Hu, Yu ; Zhu, Qingqing; Wang, Yawei; Liao, Chunyang; Jiang, Guibin
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| 2022-07-15 | |
| Source Publication | SCIENCE OF THE TOTAL ENVIRONMENT
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| ISSN | 0048-9697 |
| Volume | 830Issue:0Pages:154775 |
| Abstract | Antibiotics play a role in preventing and treating infectious diseases and also contribute to other health risks for humans. With the overuse of antibiotics, they are widely distributed in the environment. Long-term exposure to multiple antibiotics may occur in humans through medication and dietary intake. Therefore, it is critical to estimate daily intake and health risk of antibiotics based on urinary biomonitoring. This review compares the strengths and weaknesses of current analytical methods to determine antibiotics in urine samples, discusses the urinary concentration profiles and hazard quotients of individual antibiotics, and overviews correlations of antibiotic exposure with the risk of diseases. Liquid chromatography-tandem mass spectrometry is most applied to simultaneously determine multiple types of antibiotics at trace levels. Solid-phase extraction with a hydrophilic-lipophilic balance adsorbent is commonly used to extract antibiotics in urine samples. Fifteen major antibiotics with relatively higher detection frequencies and concentrations include sulfaclozine, trimethoprim, erythromycin, azithromycin, penicillin V, amoxicillin, oxytetracycline, chlortetracycline, tetracycline, doxycycline, ofloxacin, enrofloxacin, ciprofloxacin, norfloxacin, and florfenicol. Humans can be easily at microbiological effect-based risk induced by florfenicol, ciprofloxacin, azithromycin, and amoxicillin. Positive associations were observed between specific antibiotic exposure and obesity, allergic diseases, and mental disorders. Overall, the accessible, automated, and environmentally friendly methods are prospected for simultaneous determinations of antibiotics at trace level in urine. To estimate human exposure to antibiotics more accurately, knowledge gaps need to be filled up, including the transformation between parent and metabolic antibiotics, urinary excretion proportions of antibiotics at low-dose exposure and pharmacokinetic data of antibiotics in humans, and the repeated sampling over a long period in future research is needed. Longitudinal studies about antibiotic exposure and the risk of diseases in different developmental windows as well as in-depth research on the pathogenic mechanism of long-term, low-dose, and joint antibiotic exposure are warranted. |
| Department | 环境化学与生态毒理学国家重点实验室 ; 环境化学与生态毒理学国家重点实验室 |
| Keyword | PERFORMANCE LIQUID-CHROMATOGRAPHY SOLID-PHASE MICROEXTRACTION PERSONAL CARE PRODUCTS BETA-LACTAM ANTIBIOTICS MACROLIDE ANTIBIOTICS GUT-MICROBIOTA VETERINARY ANTIBIOTICS WASTE-WATER SELECTIVE QUANTIFICATION AQUATIC ENVIRONMENTS |
| Document Type | 期刊论文 |
| Identifier | https://ir.rcees.ac.cn/handle/311016/47457 |
| Collection | 环境化学与生态毒理学国家重点实验室 |
| Corresponding Author | Liao, Chunyang |
| Affiliation | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.UCAS, Sch Environm, Hangzhou Inst Adv Study, Hangzhou 310024, Zhejiang, Peoples R China 3.Jianghan Univ, Sch Environm & Hlth, Hubei Key Lab Environm & Hlth Effects Persistent, Wuhan 00056, Hubei, Peoples R China 4.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Hu, Yu,Zhu, Qingqing,Wang, Yawei,et al. A short review of human exposure to antibiotics based on urinary biomonitoring[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,830(0):154775. |
| APA | Hu, Yu,Zhu, Qingqing,Wang, Yawei,Liao, Chunyang,&Jiang, Guibin.(2022).A short review of human exposure to antibiotics based on urinary biomonitoring.SCIENCE OF THE TOTAL ENVIRONMENT,830(0),154775. |
| MLA | Hu, Yu,et al."A short review of human exposure to antibiotics based on urinary biomonitoring".SCIENCE OF THE TOTAL ENVIRONMENT 830.0(2022):154775. |
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