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Brain Accumulation and Toxicity Profiles of Silica Nanoparticles: The Influence of Size and Exposure Route
Wei, Wei; Yan, Ziyi; Liu, Xuting; Qin, Zongming; Tao, Xiaoqi; Zhu, Xiaokang; Song, Erqun; Chen, Chunying; Ke, Pu Chun; Leong, David Tai; Song, Yang
2022-06-21
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume56Issue:12Pages:8319-8325
AbstractNanoparticles (NPs) can make their way to the brain and cause in situ damage, which is a concern for nanomaterial application and airborne particulate matter exposure. Our recent study indicated that respiratory exposure to silica nanoparticles (SiO2 NPs) caused unexpected cardiovascular toxic effects. However, the toxicities of SiO2 NPs in other organs have warranted further investigation. To confirm the accumulation of SiO2 NPs in the brain, we introduced SiO2 NPs with different diameters into mice via intranasal instillation (INI) and intravenous injection (IVI) in parallel. We found that SiO2 NPs may target the brain through both olfactory and systemic routes, but the size of SiO2 NPs and delivery routes both significantly affected their brain accumulation. Surprisingly, while equivalent SiO2 NPs were found in the brain regions, brain lesions were distinctly much higher in INI than in the IVI group. Mechanistically, we showed that SiO2 NPs introduced via INI induced brain apoptosis and autophagy, while the SiO2 NPs introduced via IVI only induced autophagy in the brain.
Department环境化学与生态毒理学国家重点实验室 ; 环境化学与生态毒理学国家重点实验室
KeywordINTRANASAL DELIVERY ULTRAFINE PARTICLES OXIDE PARTICLES TRANSLOCATION AUTOPHAGY INSTILLATION MECHANISMS INHALATION PROTEINS
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/47483
Collection环境化学与生态毒理学国家重点实验室
Corresponding AuthorSong, Yang
Affiliation1.Southwest Univ, Coll Pharmaceut Sci, Minist Educ, Key Lab Luminescence Anal & Mol Sensing, Chongqing 400715, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
3.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China
4.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafty, Beijing 100190, Peoples R China
5.Chinese Acad Med Sci, Res Unit Nanosci & Technol, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Wei, Wei,Yan, Ziyi,Liu, Xuting,et al. Brain Accumulation and Toxicity Profiles of Silica Nanoparticles: The Influence of Size and Exposure Route[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022,56(12):8319-8325.
APA Wei, Wei.,Yan, Ziyi.,Liu, Xuting.,Qin, Zongming.,Tao, Xiaoqi.,...&Song, Yang.(2022).Brain Accumulation and Toxicity Profiles of Silica Nanoparticles: The Influence of Size and Exposure Route.ENVIRONMENTAL SCIENCE & TECHNOLOGY,56(12),8319-8325.
MLA Wei, Wei,et al."Brain Accumulation and Toxicity Profiles of Silica Nanoparticles: The Influence of Size and Exposure Route".ENVIRONMENTAL SCIENCE & TECHNOLOGY 56.12(2022):8319-8325.
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