| Brain Accumulation and Toxicity Profiles of Silica Nanoparticles: The Influence of Size and Exposure Route | |
Wei, Wei ; Yan, Ziyi; Liu, Xuting; Qin, Zongming; Tao, Xiaoqi; Zhu, Xiaokang; Song, Erqun; Chen, Chunying; Ke, Pu Chun; Leong, David Tai; Song, Yang
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| 2022-06-21 | |
| Source Publication | ENVIRONMENTAL SCIENCE & TECHNOLOGY
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| ISSN | 0013-936X |
| Volume | 56Issue:12Pages:8319-8325 |
| Abstract | Nanoparticles (NPs) can make their way to the brain and cause in situ damage, which is a concern for nanomaterial application and airborne particulate matter exposure. Our recent study indicated that respiratory exposure to silica nanoparticles (SiO2 NPs) caused unexpected cardiovascular toxic effects. However, the toxicities of SiO2 NPs in other organs have warranted further investigation. To confirm the accumulation of SiO2 NPs in the brain, we introduced SiO2 NPs with different diameters into mice via intranasal instillation (INI) and intravenous injection (IVI) in parallel. We found that SiO2 NPs may target the brain through both olfactory and systemic routes, but the size of SiO2 NPs and delivery routes both significantly affected their brain accumulation. Surprisingly, while equivalent SiO2 NPs were found in the brain regions, brain lesions were distinctly much higher in INI than in the IVI group. Mechanistically, we showed that SiO2 NPs introduced via INI induced brain apoptosis and autophagy, while the SiO2 NPs introduced via IVI only induced autophagy in the brain. |
| Department | 环境化学与生态毒理学国家重点实验室 ; 环境化学与生态毒理学国家重点实验室 |
| Keyword | INTRANASAL DELIVERY ULTRAFINE PARTICLES OXIDE PARTICLES TRANSLOCATION AUTOPHAGY INSTILLATION MECHANISMS INHALATION PROTEINS |
| Document Type | 期刊论文 |
| Identifier | https://ir.rcees.ac.cn/handle/311016/47483 |
| Collection | 环境化学与生态毒理学国家重点实验室 |
| Corresponding Author | Song, Yang |
| Affiliation | 1.Southwest Univ, Coll Pharmaceut Sci, Minist Educ, Key Lab Luminescence Anal & Mol Sensing, Chongqing 400715, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 4.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafty, Beijing 100190, Peoples R China 5.Chinese Acad Med Sci, Res Unit Nanosci & Technol, Beijing 100039, Peoples R China |
| Recommended Citation GB/T 7714 | Wei, Wei,Yan, Ziyi,Liu, Xuting,et al. Brain Accumulation and Toxicity Profiles of Silica Nanoparticles: The Influence of Size and Exposure Route[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022,56(12):8319-8325. |
| APA | Wei, Wei.,Yan, Ziyi.,Liu, Xuting.,Qin, Zongming.,Tao, Xiaoqi.,...&Song, Yang.(2022).Brain Accumulation and Toxicity Profiles of Silica Nanoparticles: The Influence of Size and Exposure Route.ENVIRONMENTAL SCIENCE & TECHNOLOGY,56(12),8319-8325. |
| MLA | Wei, Wei,et al."Brain Accumulation and Toxicity Profiles of Silica Nanoparticles: The Influence of Size and Exposure Route".ENVIRONMENTAL SCIENCE & TECHNOLOGY 56.12(2022):8319-8325. |
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