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Disordered Maternal and Fetal Iron Metabolism Occurs in Preterm Births in Human
Liu, Wei; Wu, Yue; Zhang, Na; Liu, Sijin; Zhou, Li
2022-08-22
Source PublicationDISEASE MARKERS
ISSN0278-0240
Volume2022Issue:0Pages:1664474
AbstractBackground. Increasing evidence reveals that iron deficiency during pregnancy causes adverse pregnancy outcomes. Thus far, the mechanisms underlying iron deficiency-associated preterm birth are mostly limited to animal studies. Whether the suggested mechanisms exist in human requires further investigation. The goal of this study was to characterize the iron metabolism in both the maternal side and fetal side in pregnant women with preterm birth. Methods. Serum and placenta samples were collected from 42 pregnant women divided into four groups according to the gestational week. Indicators of iron metabolism, including serum iron, serum hepcidin, placental tissue iron, ferroportin (FPN), transferrin receptor 1 (TfR1), and ferritin, were surveyed using enzyme-linked immunosorbent assays (Elisa), Western blots, and real-time quantitative polymerase chain reactions (qRT-PCR). Results. Significant reduction of maternal serum iron was observed in women with preterm birth relative to those with full-term birth, indicative of worsen iron deficiency in those mothers with preterm birth. Meanwhile, the maternal hepcidin levels were notably diminished in women with preterm birth, whereas the fetal hepcidin levels were comparable between the two groups. Moreover, the placental iron stores were remarkably reduced in the preterm group, associated with reduced concentration of TfR1 and increased FPN concentration relative to the normal controls. In other words, the ratio of placental FPN mass to TfR1 mass (PIDI index) was strikingly increased in the preterm group. Conclusions. Dysregulated iron homeostasis in both the maternal and fetal sides was implicated in preterm births, and disordered regulations in maintaining the placental iron equilibrium were also presumed to account for the compromised fetal iron supply.
Department环境化学与生态毒理学国家重点实验室 ; 环境化学与生态毒理学国家重点实验室
KeywordHEPCIDIN CONCENTRATIONS DEFICIENCY HOMEOSTASIS PREGNANCY RISK POSTPARTUM ANEMIA WOMEN
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/47509
Collection环境化学与生态毒理学国家重点实验室
Corresponding AuthorZhou, Li
Affiliation1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing 100026, Peoples R China
4.Beijing Maternal & Child Hlth Care Hosp, Beijing 100026, Peoples R China
Recommended Citation
GB/T 7714
Liu, Wei,Wu, Yue,Zhang, Na,et al. Disordered Maternal and Fetal Iron Metabolism Occurs in Preterm Births in Human[J]. DISEASE MARKERS,2022,2022(0):1664474.
APA Liu, Wei,Wu, Yue,Zhang, Na,Liu, Sijin,&Zhou, Li.(2022).Disordered Maternal and Fetal Iron Metabolism Occurs in Preterm Births in Human.DISEASE MARKERS,2022(0),1664474.
MLA Liu, Wei,et al."Disordered Maternal and Fetal Iron Metabolism Occurs in Preterm Births in Human".DISEASE MARKERS 2022.0(2022):1664474.
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