| Exposure levels of PCDD/Fs and PCBs in human blood and the transplacental transfer characteristics in cord blood of newborns near the industrialized area | |
Han, Ying; Liu, Wenbin ; Lei, Rongrong; Wang, Mingxin; Xue, Yingang
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| 2022-09-01 | |
| Source Publication | CHEMOSPHERE
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| ISSN | 0045-6535 |
| Volume | 303Issue:0Pages:134995 |
| Abstract | Mono-to octa-chlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) in pooled blood from the general population living near a typical industrialized area were investigated. Less chlorinated PCDD/Fs (mean: 2602 pg L-1) were 7.5 times those of highly chlorinated ones (mean: 349 pg L-1). The average sigma PCBs and sigma dl-PCBs concentrations in human (cord) blood were 2741 (117) and 18 (0.31) ng L-1, respectively. Higher concentrations of highly chlorinated PCDD/Fs were found in females than in males across different ages. The mean concentrations (and toxic equivalents (TEQs)) of PCDD/Fs were 282 (27) pg L-1 in males and 312 (32) pg L-1 in females. The concentrations of the PCDD/Fs and PCBs increased with age for both males and females, which might be caused by the long half-lives of these compounds and decreases in metabolic rates with age as the metabolic of nutrients, food, and also PCDD/Fs and PCBs would trend to slow. The TEQ of total PCDD/Fs and PCBs was higher in blood from orthopedics patients (107 pg L-1) than other patients. This result may be associated with the bone density and pollutant bioaccumulation. In addition, total concentration of PCDD/Fs and PCBs in blood of women at reproductive age were 6.6 and 37 times the cord blood of newborns, respectively. Positive correlation of PCDD/Fs and PCBs especially for the higher chlorinated compounds between female and cord blood were discovered, which might be caused by the transplacental transfer characteristics and blood barrier for macromolecules and reduce the chemical exposure risks for newborns. |
| Department | 环境化学与生态毒理学国家重点实验室 ; 环境化学与生态毒理学国家重点实验室 |
| Keyword | OCTA-CHLORINATED PCDD/FS PERSISTENT ORGANIC POLLUTANTS DIBENZO-P-DIOXINS POLYCHLORINATED-BIPHENYLS GENERAL-POPULATION PRENATAL EXPOSURES MONO SERUM MILK METABOLISM |
| Document Type | 期刊论文 |
| Identifier | https://ir.rcees.ac.cn/handle/311016/47534 |
| Collection | 环境化学与生态毒理学国家重点实验室 |
| Corresponding Author | Liu, Wenbin |
| Affiliation | 1.Changzhou Univ, Sch Environm & Safety Engn, Changzhou 213164, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.UCAS, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China 4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China |
| Recommended Citation GB/T 7714 | Han, Ying,Liu, Wenbin,Lei, Rongrong,et al. Exposure levels of PCDD/Fs and PCBs in human blood and the transplacental transfer characteristics in cord blood of newborns near the industrialized area[J]. CHEMOSPHERE,2022,303(0):134995. |
| APA | Han, Ying,Liu, Wenbin,Lei, Rongrong,Wang, Mingxin,&Xue, Yingang.(2022).Exposure levels of PCDD/Fs and PCBs in human blood and the transplacental transfer characteristics in cord blood of newborns near the industrialized area.CHEMOSPHERE,303(0),134995. |
| MLA | Han, Ying,et al."Exposure levels of PCDD/Fs and PCBs in human blood and the transplacental transfer characteristics in cord blood of newborns near the industrialized area".CHEMOSPHERE 303.0(2022):134995. |
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