| HIF-1alpha/VEGF pathway mediates 1,3,6,8-tetrabromo-9 H-carbazole-induced angiogenesis: a potential vascular toxicity of an emerging contaminant | |
Xu, Tong ; Hu, Xiaoxu; Yang, Guanglei; Liu, Yiyun; Zhang, Qian; Yu, Shuyuan; Chen, Guomin; Li, Yunping; Sha, Rui; Chen, Yangsheng; Xie, Heidi Qunhui; Guo, Tai L.; Xu, Li; Zhao, Bin
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| 2022-06-15 | |
| Source Publication | JOURNAL OF HAZARDOUS MATERIALS
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| ISSN | 0304-3894 |
| Volume | 432Issue:0Pages:128718 |
| Abstract | The dioxin-like substances polyhalogenated carbazoles (PHCZs) may trigger the aryl hydrocarbon receptor (AhR) signaling pathway. Although the crosstalk between AhR and the hypoxia inducible factor-1 (HIF-1) pathways is generally believed to occur, the exact mechanisms of the HIF-1 pathway in PHCZ toxicity have not been determined. We aimed to elucidate the effect of PHCZs on the HIF-1 pathway and its involvement in the regulation of target genes of HIF-1. Herein, we employed human HepG2 cells transiently transfected with a hypoxia response element (HRE) luciferase reporter to identify PHCZs that could influence HIF-1 pathway. We found that exposure to one of the four selected PHCZs, specifically 1,3,6,8-tetrabromo-9 H-carbazole (1368-BCZ), induced a significant enhancement of the activity of HRE activity. In silico data supported 1368-BCZ-induced HIF-1 alpha activity preferentially. Moreover, 1368-BCZ significantly upregulated the expression of HIF-1 target genes, including endothelial growth factor (VEGF) and erythropoietin. Importantly, the stimulated secretion of VEGF by 1368-BCZ promoted the angiogenesis in human umbilical vein endothelial cells. Therefore, the present |
| Department | 环境化学与生态毒理学国家重点实验室 ; 环境化学与生态毒理学国家重点实验室 |
| Keyword | ARYL-HYDROCARBON RECEPTOR HALOGENATED CARBAZOLES TUMOR ANGIOGENESIS HYPOXIA DIOXIN VEGF HIF-1-ALPHA SYSTEM CANCER OXYGEN |
| Document Type | 期刊论文 |
| Identifier | https://ir.rcees.ac.cn/handle/311016/47544 |
| Collection | 环境化学与生态毒理学国家重点实验室 |
| Corresponding Author | Xu, Li |
| Affiliation | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Beijing Hosp, Natl Ctr Gerontol, Dept Cardiol, Beijing 100730, Peoples R China 4.Shenzhen Ctr Dis Control & Prevent, Environm & Hlth Dept, Shenzhen 518055, Guangdong, Peoples R China 5.Univ Chinese Acad Sci, Sch Environm, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China |
| Recommended Citation GB/T 7714 | Xu, Tong,Hu, Xiaoxu,Yang, Guanglei,et al. HIF-1alpha/VEGF pathway mediates 1,3,6,8-tetrabromo-9 H-carbazole-induced angiogenesis: a potential vascular toxicity of an emerging contaminant[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,432(0):128718. |
| APA | Xu, Tong.,Hu, Xiaoxu.,Yang, Guanglei.,Liu, Yiyun.,Zhang, Qian.,...&Zhao, Bin.(2022).HIF-1alpha/VEGF pathway mediates 1,3,6,8-tetrabromo-9 H-carbazole-induced angiogenesis: a potential vascular toxicity of an emerging contaminant.JOURNAL OF HAZARDOUS MATERIALS,432(0),128718. |
| MLA | Xu, Tong,et al."HIF-1alpha/VEGF pathway mediates 1,3,6,8-tetrabromo-9 H-carbazole-induced angiogenesis: a potential vascular toxicity of an emerging contaminant".JOURNAL OF HAZARDOUS MATERIALS 432.0(2022):128718. |
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