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Identification of two-dimensional copper signatures in human blood for bladder cancer with machine learning
Wang, Weichao; Liu, Xian; Zhang, Changwen; Sheng, Fei; Song, Shanjun; Li, Penghui; Dai, Shaoqing; Wang, Bin; Lu, Dawei; Zhang, Luyao; Yang, Xuezhi; Zhang, Zhihong; Liu, Sijin; Zhang, Aiqian; Liu, Qian; Jiang, Guibin
2022-02-09
Source PublicationCHEMICAL SCIENCE
ISSN2041-6520
Volume13Issue:6Pages:1648-1656
AbstractCurrently, almost all available cancer biomarkers are based on concentrations of compounds, often suffering from low sensitivity, poor specificity, and false positive or negative results. The stable isotopic composition of elements provides a different dimension from the concentration and has been widely used as a tracer in geochemistry. In health research, stable isotopic analysis has also shown potential as a new diagnostic/prognostic tool, which is still in the nascent stage. Here we discovered that bladder cancer (BCa) could induce a significant variation in the ratio of natural copper isotopes (Cu-65/Cu-63) in the blood of patients relative to benign and healthy controls. Such inherent copper isotopic signatures permitted new insights into molecular mechanisms of copper imbalance underlying the carcinogenic process. More importantly, to enhance the diagnostic capability, a machine learning model was developed to classify BCa and non-BCa subjects based on two-dimensional copper signatures (copper isotopic composition and concentration in plasma and red blood cells) with a high sensitivity, high true negative rate, and low false positive rate. Our results demonstrated the promise of blood copper signatures combined with machine learning as a versatile tool for cancer research and potential clinical application.
Department环境化学与生态毒理学国家重点实验室 ; 环境化学与生态毒理学国家重点实验室
KeywordICP-MASS SPECTROMETRY ISOTOPE FRACTIONATION HEPATOCELLULAR-CARCINOMA MEDICAL APPLICATIONS OXIDATIVE STRESS TRACE-ELEMENTS CELL CARCINOMA SERUM CU ZN
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/47550
Collection环境化学与生态毒理学国家重点实验室
Corresponding AuthorLiu, Qian
Affiliation1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
2.Tianjin Med Univ, Tianjin Inst Urol, Dept Urol, Hosp 2, Tianjin 300211, Peoples R China
3.Natl Inst Metrol, Beijing 100029, Peoples R China
4.Tianjin Univ Technol, Tianjin 300384, Peoples R China
5.Univ Twente, Fac Geoinformat Sci & Earth Observat ITC, POB 217, NL-7500 AE Enschede, Netherland
Recommended Citation
GB/T 7714
Wang, Weichao,Liu, Xian,Zhang, Changwen,et al. Identification of two-dimensional copper signatures in human blood for bladder cancer with machine learning[J]. CHEMICAL SCIENCE,2022,13(6):1648-1656.
APA Wang, Weichao.,Liu, Xian.,Zhang, Changwen.,Sheng, Fei.,Song, Shanjun.,...&Jiang, Guibin.(2022).Identification of two-dimensional copper signatures in human blood for bladder cancer with machine learning.CHEMICAL SCIENCE,13(6),1648-1656.
MLA Wang, Weichao,et al."Identification of two-dimensional copper signatures in human blood for bladder cancer with machine learning".CHEMICAL SCIENCE 13.6(2022):1648-1656.
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