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Internal Exposure and Distribution of Airborne Fine Particles in the Human Body: Methodology, Current Understandings, and ResearchNeeds
Wang, Weichao; Lin, Yue; Yang, Hang; Ling, Weibo; Liu, Lin; Zhang, Weican; Lu, Dawei; Liu, Qian; Jiang, Guibin
2022-06-07
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume56Issue:11Pages:6857-6869
AbstractExposure to airbornefine particles (PM2.5, particulate matter with aerodynamicdiameter <2.5 mu m) severely threatens global human health. Understanding the distribution andprocesses of inhaled PM2.5in the human body is crucial to clarify the causal links betweenPM2.5pollution and diseases. In contrast to extensive research on the emission and formationof PM2.5in the ambient environment, reports about the occurrence and fate of PM2.5inhumans are still limited, although many studies have focused on the exposure and adverseeffects of PM2.5with animal models. It has been shown that PM2.5, especially ultrafine particles(UFPs), have the potential to go across different biological barriers and translocate intodifferent human organs (i.e., blood circulation, brain, heart, pleural cavity, and placenta). Inthis Perspective, we summarize the factors affecting the internal exposure of PM2.5and therelevant analytical methodology and review current knowledge about the exposure pathwaysand distribution of PM2.5in humans. We also discuss the research challenges and call for morestudies on the identification and characterization of key toxic species of PM2.5, quantification ofinternal exposure doses in the general population, and further clarification of translocation,metabolism, and clearance pathways of PM2.5in the human body. In this way, it is possible to develop toxicity-based air qualitystandards instead of the currently used mass-based standards.
Department环境化学与生态毒理学国家重点实验室 ; 环境化学与生态毒理学国家重点实验室
KeywordWALLED CARBON NANOTUBES POLYCYCLIC AROMATIC-HYDROCARBONS AMBIENT AIR-POLLUTION SILVER NANOPARTICLES SILICA NANOPARTICLES ULTRAFINE PARTICLES CHRONIC INHALATION MASS-SPECTROMETRY YOUNG URBANITES MATTER
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/47557
Collection环境化学与生态毒理学国家重点实验室
Corresponding AuthorLiu, Qian
Affiliation1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100190, Peoples R China
3.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Peoples R China
Recommended Citation
GB/T 7714
Wang, Weichao,Lin, Yue,Yang, Hang,et al. Internal Exposure and Distribution of Airborne Fine Particles in the Human Body: Methodology, Current Understandings, and ResearchNeeds[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022,56(11):6857-6869.
APA Wang, Weichao.,Lin, Yue.,Yang, Hang.,Ling, Weibo.,Liu, Lin.,...&Jiang, Guibin.(2022).Internal Exposure and Distribution of Airborne Fine Particles in the Human Body: Methodology, Current Understandings, and ResearchNeeds.ENVIRONMENTAL SCIENCE & TECHNOLOGY,56(11),6857-6869.
MLA Wang, Weichao,et al."Internal Exposure and Distribution of Airborne Fine Particles in the Human Body: Methodology, Current Understandings, and ResearchNeeds".ENVIRONMENTAL SCIENCE & TECHNOLOGY 56.11(2022):6857-6869.
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