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Monitoring the Cd2+ release from Cd-containing quantum dots in simulated body fluids by size exclusion chromatography coupled with ICP-MS
Lai, Yujian; Dong, Lijie; Sheng, Xueying; Chao, Jingbo; Yu, Sujuan; Liu, Jingfu
2022-07
Source PublicationANALYTICAL AND BIOANALYTICAL CHEMISTRY
ISSN1618-2642
Volume414Issue:18Pages:5529-5536
AbstractQuantification of Cd2+ release from Cd-containing quantum dots (QDs) is of fundamental importance to elucidate its toxicity to organisms, but remains a great challenge due to the lack of appropriate analytical method. Herein, a facile method based on size exclusion chromatography (SEC) combined with inductively coupled plasma mass spectrometry (ICP-MS) was developed for separating and quantifying the QDs and counterpart ions. By using the mixture of sodium dodecyl sulfate (SDS) and ethylenediaminetetraacetic acid tetrasodium salt (EDTA) as the mobile phase, the defect of QD and ion adsorption onto the SEC column was overcome, thus realizing the accurate quantification of ionic species. Besides, the concentration of QDs was achieved through subtracting the ion concentration from the total concentration. Selecting CdSe@ZnS as the typical QDs, the Cd2+ release process in four typical simulated body fluids, namely, simulated gastric fluid, simulated sweat, Gamble's solution, and artificial lysosomal fluid, was monitored using the developed SEC-ICP-MS method. The media pH is identified as the decisive factor which controls the dissolution of ZnS shells and also the Cd2+ release kinetics and final concentration. Our results suggest that the oral pathway for QD uptake poses the biggest risk to human health.
Department环境化学与生态毒理学国家重点实验室 ; 环境化学与生态毒理学国家重点实验室
KeywordNANOPARTICLES CYTOTOXICITY DISSOLUTION SEPARATION QUANTIFICATION AGGREGATION SILVER
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/47580
Collection环境化学与生态毒理学国家重点实验室
Corresponding AuthorLiu, Jingfu
Affiliation1.UCAS, Hangzhou Inst Adv Study, Sch Environm, Hangzhou 310024, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, POB 2871, Beijing 100085, Peoples R China
3.Natl Inst Metrol, Div Chem Metrol & Analyt Chem, Beijing 100029, Peoples R China
4.China Univ Petr, Coll Chem Engn & Environm, State Key Lab Heavy Oil Proc, Beijing 102249, Peoples R China
5.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Peoples R China
Recommended Citation
GB/T 7714
Lai, Yujian,Dong, Lijie,Sheng, Xueying,et al. Monitoring the Cd2+ release from Cd-containing quantum dots in simulated body fluids by size exclusion chromatography coupled with ICP-MS[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2022,414(18):5529-5536.
APA Lai, Yujian,Dong, Lijie,Sheng, Xueying,Chao, Jingbo,Yu, Sujuan,&Liu, Jingfu.(2022).Monitoring the Cd2+ release from Cd-containing quantum dots in simulated body fluids by size exclusion chromatography coupled with ICP-MS.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,414(18),5529-5536.
MLA Lai, Yujian,et al."Monitoring the Cd2+ release from Cd-containing quantum dots in simulated body fluids by size exclusion chromatography coupled with ICP-MS".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 414.18(2022):5529-5536.
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