Palladium Nanoplate-Based IL-6 Receptor Antagonists Ameliorate Cancer-Related Anemia and Simultaneously Inhibit Cancer Progression

	Palladium Nanoplate-Based IL-6 Receptor Antagonists Ameliorate Cancer-Related Anemia and Simultaneously Inhibit Cancer Progression
	Zhu, Jianqiang ; Fu, Qingfeng ; Wang, Shunhao ; Ren, Liting ; Feng, Wenya ; Wei, Shuting ; Zhang, Zhihong ; Xu, Yong ; Ganz, Tomas ; Liu, Sijin
	2022-01-26
Source Publication	NANO LETTERS
ISSN	1530-6984
Volume	22 Issue:2 Pages:751-760
Abstract	In recent years, targeted therapies and immunotherapeutics, along with conventional chemo- and radiotherapy, have greatly improved cancer treatments. Unfortunately, in cancer patients, anemia, either as a complication of cancer progression or as the result of cancer treatment, undermines the expected therapeutic efficacy. Here, we developed a smart nanosystem based on the palladium nanoplates (PdPLs) to deliver tocilizumab (TCZ, a widely used IL-6R antibody) to the liver for specific blockade of IL-6/IL-6R signaling to correct anemia. With chemical modifications, this nanosystem delivered a large mass of TCZ and enhanced liver delivery, inducing a marked suppression of hepcidin expression as a result of diminished IL-6 signaling. Through this mechanism, significant suppression of tumor progression was realized (at least in part) because of the corrected anemia after treatment.
Department	环境化学与生态毒理学国家重点实验室 ; 环境化学与生态毒理学国家重点实验室
Keyword	PD NANOSHEETS MOUSE MODEL INFLAMMATION TOCILIZUMAB IRON NANOPARTICLES PATHOGENESIS PREVALENCE PROMOTES
Document Type	期刊论文
Identifier	https://ir.rcees.ac.cn/handle/311016/47596
Collection	环境化学与生态毒理学国家重点实验室
Affiliation	1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Tianjin Med Univ, Tianjin Inst Urol, Dept Urol, Hosp 2, Tianjin 300211, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
Recommended Citation GB/T 7714	Zhu, Jianqiang,Fu, Qingfeng,Wang, Shunhao,et al. Palladium Nanoplate-Based IL-6 Receptor Antagonists Ameliorate Cancer-Related Anemia and Simultaneously Inhibit Cancer Progression[J]. NANO LETTERS,2022,22(2):751-760.
APA	Zhu, Jianqiang.,Fu, Qingfeng.,Wang, Shunhao.,Ren, Liting.,Feng, Wenya.,...&Liu, Sijin.(2022).Palladium Nanoplate-Based IL-6 Receptor Antagonists Ameliorate Cancer-Related Anemia and Simultaneously Inhibit Cancer Progression.NANO LETTERS,22(2),751-760.
MLA	Zhu, Jianqiang,et al."Palladium Nanoplate-Based IL-6 Receptor Antagonists Ameliorate Cancer-Related Anemia and Simultaneously Inhibit Cancer Progression".NANO LETTERS 22.2(2022):751-760.

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