RCEES OpenIR  > 环境化学与生态毒理学国家重点实验室
Passive Smoking Exposure Modifies Cardiovascular Structure and Function: Beijing Child Growth and Health Cohort (PROC) Study
Xiao, Huidi; Li, Menglong; Li, Aijing; Amaerjiang, Nubiya; Zunong, Jiawulan; Vermund, Sten H.; Perez-Escamilla, Rafael; Song, Maoyong; Hu, Yifei; Jiang, Guibin
2022-09-15
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Issue0Pages:1-9
AbstractPassive smoking exposure in children is prevalent worldwide and exposes children to respiratory and systemic toxins. In this study, we enrolled 568 children to study how secondhand smoke (SHS) might affect children's cardiovascular health in China. The measurement of nicotine and its metabolites in urine showed that 78.9% of children were exposed to SHS. Children exposed to SHS had greater interventricular septum thickness (p = 0.005) and left ventricular mass index (p = 0.008) than nonexposed children. Urinary norcotinine levels were associated with increased ascending aorta diameter (beta = 0.10, 95%CI 0.02-0.17) and decreased left ventricular end systolic diameter (beta = -0.10, 95%CI -0.19 to - 0.01). The effects of SHS exposure on cardiovascular function: norcotinine levels associated with lower left ventricular mass index (beta = -0.32, 95%CI -0.59 to -0.05), left ventricular end diastolic volume index (beta = -0.43, 95%CI -0.85 to -0.02), and left ventricular end systolic volume index (beta = -0.20, 95%CI -0.37 to - 0.03). Moreover, there no no significant associations of nicotine, cotinine, and trans-3 '-hydroxycotinine with cardiovascular health. Overall, SHS exposure in children remains prevalent in Beijing and may affect children's cardiovascular development, in both structure and function. It suggests that stricter and practical measures are needed toward the elimination of tobacco use in children's environments.
Department环境化学与生态毒理学国家重点实验室 ; 环境化学与生态毒理学国家重点实验室
KeywordSECONDHAND SMOKE PARENTAL SMOKING ATRIAL-FIBRILLATION RISK ASSOCIATION ADULTHOOD DISEASE HYPERTENSION ADOLESCENTS PREVALENCE
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/47598
Collection环境化学与生态毒理学国家重点实验室
Affiliation1.Capital Med Univ, Sch Publ Hlth, Dept Child Adolescent Hlth & Maternal Care, Beijing 100069, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Yale Univ, Yale Sch Publ Hlth, New Haven, CT 06510 USA
5.Capital Med Univ, Sch Publ Hlth, Beijing Key Lab Environm Toxicol, Beijing 100069, Peoples R Ch
Recommended Citation
GB/T 7714
Xiao, Huidi,Li, Menglong,Li, Aijing,et al. Passive Smoking Exposure Modifies Cardiovascular Structure and Function: Beijing Child Growth and Health Cohort (PROC) Study[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022(0):1-9.
APA Xiao, Huidi.,Li, Menglong.,Li, Aijing.,Amaerjiang, Nubiya.,Zunong, Jiawulan.,...&Jiang, Guibin.(2022).Passive Smoking Exposure Modifies Cardiovascular Structure and Function: Beijing Child Growth and Health Cohort (PROC) Study.ENVIRONMENTAL SCIENCE & TECHNOLOGY(0),1-9.
MLA Xiao, Huidi,et al."Passive Smoking Exposure Modifies Cardiovascular Structure and Function: Beijing Child Growth and Health Cohort (PROC) Study".ENVIRONMENTAL SCIENCE & TECHNOLOGY .0(2022):1-9.
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