Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling

	Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling
	Ren, Zhihua ; Ku, Tingting ; Gao, Yurou ; Yang, Xiaoxi; Meng, Lingyi ; Liu, Qian S.; Liang, Jiefeng ; Xu, Hanqing; Liao, Chunyang; Zhou, Qunfang; Faiola, Francesco; Jiang, Guibin
	2022-06-21
Source Publication	ENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN	0013-936X
Volume	56 Issue:12 Pages:8496-8506
Abstract	The neurodevelopmental process is highly vulnerable to environmental stress from exposure to endocrine-disrupting chemicals. Perfluorinated iodine alkanes (PFIs) possess estrogenic activities, while their potential neurodevelopmental toxicity remains blurry. In the present study, the effects of two PFIs, including dodecafluoro-1,6-diiodohexane (PFHxDI) and tridecafluorohexyl iodide (PFHxI), were investigated in the neural differentiation of the mouse embryonic stem cells (mESCs). Without influencing the cytobiological process of the mESCs, PFIs interfered the triploblastic development by increasing ectodermal differentiation, thus promoting subsequent neurogenesis. The temporal regulation of PFIs in Notch-Hes signaling through the targeting of mmumiRNA-34a-5p provided a substantial explanation for the underlying mechanism of PFI-promoted mESC commitment to the neural lineage. The findings herein provided new knowledge on the potential neurodevelopmental toxicities of PFIs, which would help advance the health risk assessment of these kinds of emerging chemicals.
Department	环境化学与生态毒理学国家重点实验室 ; 环境化学与生态毒理学国家重点实验室
Keyword	ENDOCRINE-DISRUPTING CHEMICALS EMBRYONIC STEM-CELLS ESTROGEN-RECEPTOR-ALPHA IN-VITRO BISPHENOL-A GENERATION EXPOSURE BINDING
Document Type	期刊论文
Identifier	https://ir.rcees.ac.cn/handle/311016/47600
Collection	环境化学与生态毒理学国家重点实验室
Corresponding Author	Zhou, Qunfang
Affiliation	1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 3.Shanxi Univ, Coll Environm & Resource, Res Ctr Environm & Hlth, Taiyuan 030006, Peoples R China 4.Univ Chinese Acad Sci, Coll Sino Danish, Beijing 100049, Peoples R China 5.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Peoples R China
Recommended Citation GB/T 7714	Ren, Zhihua,Ku, Tingting,Gao, Yurou,et al. Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022,56(12):8496-8506.
APA	Ren, Zhihua.,Ku, Tingting.,Gao, Yurou.,Yang, Xiaoxi.,Meng, Lingyi.,...&Jiang, Guibin.(2022).Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling.ENVIRONMENTAL SCIENCE & TECHNOLOGY,56(12),8496-8506.
MLA	Ren, Zhihua,et al."Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling".ENVIRONMENTAL SCIENCE & TECHNOLOGY 56.12(2022):8496-8506.

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