| Tissue distribution of sodium p-perfluorous nonenoxybenzene sulfonate (OBS) in mice via oral exposure | |
Zhou, Longfei; He, Sisi; Shi, Yali ; Cai, Yaqi; Zhang, Chunhui
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| 2022-07 | |
| Source Publication | ENVIRONMENT INTERNATIONAL
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| ISSN | 0160-4120 |
| Volume | 165Issue:0Pages:107289 |
| Abstract | Environmental risks caused by emerging per- and polyfluoroalkyl substances (PFASs) have attracted increasing attention. As an important substitute for perfluorooctane sulfonate (PFOS), sodium p-perfluorous nonenoxybenzene sulfonate (OBS) is widely used as a firefighting foam additive and oil recovery agent in China. This study reported the tissue distribution of OBS in KM mice that were administered a dose of OBS at 10 mu g/day via daily oral gavage for 7, 14, or 28 days. During exposure, gender-based differences were observed in body weight changes and tissue distribution of OBS. Liver exhibited the highest concentrations (males: 12.57 +/- 1.80 mu g/g; females: 11.80 +/- 5.32 mu g/g) and tissue/blood ratios and contributed more than 50% to the whole-body burden of OBS in both male and female mice, showing its ability to enrich PFASs. Furthermore, there were certain differences in the distribution characteristics of the three OBS isomers. Based on its bioaccumulation potential and widespread use, further studies are required on the human exposure risks of OBS. |
| Department | 环境化学与生态毒理学国家重点实验室 ; 环境化学与生态毒理学国家重点实验室 |
| Keyword | PERFLUORINATED ACID ISOMERS GUT BARRIER DYSFUNCTION SPRAGUE-DAWLEY RATS POLYFLUOROALKYL SUBSTANCES POTASSIUM PERFLUOROOCTANESULFONATE PFOS DISPOSITION TOXICITY |
| Document Type | 期刊论文 |
| Identifier | https://ir.rcees.ac.cn/handle/311016/47633 |
| Collection | 环境化学与生态毒理学国家重点实验室 |
| Corresponding Author | Shi, Yali |
| Affiliation | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.China Univ Min & Technol Beijing, Sch Chem & Environm Engn, Beijing 100083, Peoples R China 4.UCAS, Hangzhou Inst Adv Study, Sch Environm, Hangzhou 310024, Peoples R China 5.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Peoples R China |
| Recommended Citation GB/T 7714 | Zhou, Longfei,He, Sisi,Shi, Yali,et al. Tissue distribution of sodium p-perfluorous nonenoxybenzene sulfonate (OBS) in mice via oral exposure[J]. ENVIRONMENT INTERNATIONAL,2022,165(0):107289. |
| APA | Zhou, Longfei,He, Sisi,Shi, Yali,Cai, Yaqi,&Zhang, Chunhui.(2022).Tissue distribution of sodium p-perfluorous nonenoxybenzene sulfonate (OBS) in mice via oral exposure.ENVIRONMENT INTERNATIONAL,165(0),107289. |
| MLA | Zhou, Longfei,et al."Tissue distribution of sodium p-perfluorous nonenoxybenzene sulfonate (OBS) in mice via oral exposure".ENVIRONMENT INTERNATIONAL 165.0(2022):107289. |
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| Tissue distribution （2856KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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