| Tox21-Based Comparative Analyses for the Identification of Potential Toxic Effects of Environmental Pollutants | |
Yang, Renjun ; Liu, Shuyu; Yin, Nuoya; Zhang, Yang; Faiola, Francesco
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| 2022-09-20 | |
| Source Publication | ENVIRONMENTAL SCIENCE & TECHNOLOGY
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| ISSN | 0013-936X |
| Issue | 0Pages:1-12 |
| Abstract | Chemical pollution has become a prominent environ-mental problem. In recent years, quantitative high-throughput screening (qHTS) assays have been developed for the fast assessment of chemicals' toxic effects. Toxicology in the 21st Century (Tox21) is a well-known and continuously developing qHTS project. Recent reports utilizing Tox21 data have mainly focused on setting up mathematical models for in vivo toxicity predictions, with less attention to intuitive qHTS data visualization. In this study, we attempted to reveal and summarize the toxic effects of environmental pollutants by analyzing and visualizing Tox21 qHTS data. Via PubMed text mining, toxicity/ structure clustering, and manual classification, we detected a total of 158 chemicals of environmental concern (COECs) from the Tox21 library that we classified into 13 COEC groups based on structure and activity similarities. By visualizing these COEC groups' bioactivities, we demonstrated that COECs frequently displayed androgen and progesterone antagonistic effects, xenobiotic receptor agonistic roles, and mitochondrial toxicity. We also revealed many other potential targets of the 13 COEC groups, which were not well illustrated yet, and that current Tox21 assays may not correctly classify known teratogens. In conclusion, we provide a feasible method to intuitively understand qHTS data. |
| Department | 环境化学与生态毒理学国家重点实验室 ; 环境化学与生态毒理学国家重点实验室 |
| Keyword | ORGANOPHOSPHATE FLAME RETARDANTS ESTROGEN-RECEPTOR IN-VIVO REPRODUCTIVE DEVELOPMENT TETRABROMOBISPHENOL-A ANDROGEN RECEPTOR ER-BETA PESTICIDES ATRAZINE XENOBIOTICS |
| Document Type | 期刊论文 |
| Identifier | https://ir.rcees.ac.cn/handle/311016/47636 |
| Collection | 环境化学与生态毒理学国家重点实验室 |
| Corresponding Author | Faiola, Francesco |
| Affiliation | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 3.Univ Cambridge, Dept Pathol, CRUK Gurdon Inst, Wellcome Trust, Cambridge CB2 1QN, England 4.Capital Med Univ, Beijing Friendship Hosp, Dept Pharm, Beijing 100050, Peoples R China |
| Recommended Citation GB/T 7714 | Yang, Renjun,Liu, Shuyu,Yin, Nuoya,et al. Tox21-Based Comparative Analyses for the Identification of Potential Toxic Effects of Environmental Pollutants[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022(0):1-12. |
| APA | Yang, Renjun,Liu, Shuyu,Yin, Nuoya,Zhang, Yang,&Faiola, Francesco.(2022).Tox21-Based Comparative Analyses for the Identification of Potential Toxic Effects of Environmental Pollutants.ENVIRONMENTAL SCIENCE & TECHNOLOGY(0),1-12. |
| MLA | Yang, Renjun,et al."Tox21-Based Comparative Analyses for the Identification of Potential Toxic Effects of Environmental Pollutants".ENVIRONMENTAL SCIENCE & TECHNOLOGY .0(2022):1-12. |
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| Tox21-Based Comparat（7010KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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