| Alteration of intestinal microecology by oral antibiotics promotes oral squamous cell carcinoma development | |
Wei, Wei ; Li, Jia; Liu, Fan; Wu, Miaomiao; Xiong, Kaixin; He, Qing; Zhang, Bo; Deng, Ye; Li, Yan
| |
| 2022-09-01 | |
| Source Publication | MOLECULAR IMMUNOLOGY
 |
| ISSN | 0161-5890 |
| Volume | 149Issue:0Pages:94-106 |
| Abstract | Oral antibiotics can influence cancers and immunotherapy by interfering with the intestinal microbiota. How-ever, the association between oral antibiotics and oral squamous cell carcinoma (OSCC) as well as the mecha-nisms underlying the effects of oral antibiotics on OSCC remain unclear. Here, we found that oral antibiotics cocktail (4Abx) promoted the tumor development and shifted the microbiota, decreasing the abundance of probiotic bacteria, and altered microbial metabolism in the gut of OSCC mice, increasing tyrosine and decreasing glutamate levels. In vitro experiments showed that tyrosine upregulated the PD-1 expression in T cells, SCC7 cell proliferation, and necroptosis expression. IL-10 expression level in CD11c+ cells was reduced by glutamate. Furthermore, the expression of the necroptosis-related proteins, including receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like (MLKL), was higher in the OSCC mice treated with 4Abx. Supplementation with glutamate or healthy mouse feces by gavage alleviated the tumor-promoting effect of 4Abx with restored balance of microbial metabolism. Overall, we identified the detrimental role of oral anti-biotics in promoting OSCC development through altered intestinal microbiota, microbial metabolism, and im-mune dysbiosis, implying the need for antibiotic stewardship in OSCC treatment. |
| Department | 中国科学院环境生物技术重点实验室 ; 中国科学院环境生物技术重点实验室 |
| Keyword | CANCER TYROSINE METABOLISM OPPORTUNITIES NECROPTOSIS MICROBIOME DISEASE VACCINE HEAD |
| Document Type | 期刊论文 |
| Identifier | https://ir.rcees.ac.cn/handle/311016/47768 |
| Collection | 中国科学院环境生物技术重点实验室 |
| Corresponding Author | Li, Yan |
| Affiliation | 1.Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu 610041, Peoples R China 2.Sichuan Univ, West China Hosp Stomatol, Nursing Dept, Chengdu 610041, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, CAS Key Lab Environm Biotechnol, Beijing 100085, Peoples R China 4.Hubei Minzu Univ, Dept Stomatol, Minda Hosp, Enshi 445000, Peoples R China |
| Recommended Citation GB/T 7714 | Wei, Wei,Li, Jia,Liu, Fan,et al. Alteration of intestinal microecology by oral antibiotics promotes oral squamous cell carcinoma development[J]. MOLECULAR IMMUNOLOGY,2022,149(0):94-106. |
| APA | Wei, Wei.,Li, Jia.,Liu, Fan.,Wu, Miaomiao.,Xiong, Kaixin.,...&Li, Yan.(2022).Alteration of intestinal microecology by oral antibiotics promotes oral squamous cell carcinoma development.MOLECULAR IMMUNOLOGY,149(0),94-106. |
| MLA | Wei, Wei,et al."Alteration of intestinal microecology by oral antibiotics promotes oral squamous cell carcinoma development".MOLECULAR IMMUNOLOGY 149.0(2022):94-106. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| Alteration of intest（14066KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment