RCEES OpenIR  > 中国科学院饮用水科学与技术重点实验室
Toxicity of waterborne vortioxetine, a new antidepressant, in non-target aquatic organisms: From wonder to concern drugs?
Hong, Xiangsheng; Zhang, Le; Zha, Jinmiao
2022-07-01
Source PublicationENVIRONMENTAL POLLUTION
ISSN0269-7491
Volume304Issue:0Pages:119175
AbstractVortioxetine is increasing in popularity as a treatment for major depressive disorder and has been detected in wastewater effluent. However, information on the toxicity and environmental risk of vortioxetine in non-target organisms is scarce. Here, embryonic and juvenile zebrafish (Danio rerio) were used to assess the toxicity of vortioxetine (0, 1, 10, 30, 100, 300, and 1000 mu g/L) after 120 h and 7 d of exposure, respectively. Vortioxetine induced significant toxicity during embryonic development, including effects on survival, hatching, basal heart rate, spontaneous tail coiling and developmental abnormalities, and inhibited larval locomotor activity at concentrations higher than 30 mu g/L. Additionally, vortioxetine evoked anxiolytic-like behavior and caused histopathological changes to multiple organs (gills, heart, liver and intestine) in juvenile zebrafish. Significant increase in 5-HT content was observed in whole zebrafish larvae and juvenile brain tissues from animals treated with 1 or 100 mu g/L vortioxetine. Notably, the lowest effective concentrations of vortioxetine for zebrafish were mainly in the range of 10-30 mu g/L, which were slightly lower than the vortioxetine therapeutic concentrations. Risk quotients assuming conservative exposure assessments were above one in European countries indicating moderate risk for the behavioral endpoints assessed. We believe that these results highlight the adverse effects of vortioxetine on non-target organisms and that further investigations will be required to provide a higher confidence.
Department中国科学院饮用水科学与技术重点实验室 ; 中国科学院饮用水科学与技术重点实验室
KeywordZEBRAFISH DANIO-RERIO DOUBLE-BLIND LU AA21004 SEROTONIN PLACEBO AMITRIPTYLINE TOLERABILITY INHIBITION RESPONSES EXPOSURE
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/47911
Collection中国科学院饮用水科学与技术重点实验室
Corresponding AuthorZha, Jinmiao
Affiliation1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Drinking Water Sci & Technol, 18 Shuangqing Rd, Beijing 100085, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Hong, Xiangsheng,Zhang, Le,Zha, Jinmiao. Toxicity of waterborne vortioxetine, a new antidepressant, in non-target aquatic organisms: From wonder to concern drugs?[J]. ENVIRONMENTAL POLLUTION,2022,304(0):119175.
APA Hong, Xiangsheng,Zhang, Le,&Zha, Jinmiao.(2022).Toxicity of waterborne vortioxetine, a new antidepressant, in non-target aquatic organisms: From wonder to concern drugs?.ENVIRONMENTAL POLLUTION,304(0),119175.
MLA Hong, Xiangsheng,et al."Toxicity of waterborne vortioxetine, a new antidepressant, in non-target aquatic organisms: From wonder to concern drugs?".ENVIRONMENTAL POLLUTION 304.0(2022):119175.
Files in This Item: Download All
File Name/Size DocType Version Access License
Toxicity of waterbor(7567KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hong, Xiangsheng]'s Articles
[Zhang, Le]'s Articles
[Zha, Jinmiao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hong, Xiangsheng]'s Articles
[Zhang, Le]'s Articles
[Zha, Jinmiao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hong, Xiangsheng]'s Articles
[Zhang, Le]'s Articles
[Zha, Jinmiao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Toxicity of waterborne vortioxetine, a new antidepressant, in non-target aquatic organisms_ From wonder to concern drugs.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.