| Lactate: A pearl dropped in the ocean: An overlooked signal molecule in physiology and pathology | |
Wu, Yue ; Ma, Wanqi; Liu, Wei; Zhang, Shuping
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| 2023 | |
| Source Publication | CELL BIOLOGY INTERNATIONAL
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| ISSN | 1065-6995 |
| Volume | 47Issue:2Pages:1-13 |
| Abstract | Lactate, once recognized as a wasty product from anaerobic glycolysis, is proved to be a pivotal signal molecule. Lactate accumulation occurs in diverse physiological and pathological settings due to the imbalance between lactate production and clearance. Under the condition with drastic changes in local microenvironment, such as tumorigenesis, inflammation, and microbial infection, the glycolysis turns to be active in surrounding cells leading to increased lactate release. Meanwhile, lactate can be utilized by these cells as an energy substrate and acts as a signal molecule to regulate cell functions through receptor-dependent or independent pathways. In this review, we tended to tease out the contribution of lactate in tumor progression and immunomodulation. And we also discussed the accessory role of lactate, beyond as the energy source only, in the growth of invading pathogens. |
| Department | 环境化学与生态毒理学国家重点实验室 |
| Keyword | cancer immunomodulation infection lactate signal molecule |
| Document Type | 期刊论文 |
| Identifier | https://ir.rcees.ac.cn/handle/311016/48498 |
| Collection | 环境化学与生态毒理学国家重点实验室 |
| Affiliation | 1.Chinese Academy of Sciences 2.University of Chinese Academy of Sciences, CAS 3.Shandong First Medical University & Shandong Academy of Medical Sciences 4.University of Jinan 5.Research Center for Eco-Environmental Sciences (RCEES) |
| Recommended Citation GB/T 7714 | Wu, Yue,Ma, Wanqi,Liu, Wei,et al. Lactate: A pearl dropped in the ocean: An overlooked signal molecule in physiology and pathology[J]. CELL BIOLOGY INTERNATIONAL,2023,47(2):1-13. |
| APA | Wu, Yue,Ma, Wanqi,Liu, Wei,&Zhang, Shuping.(2023).Lactate: A pearl dropped in the ocean: An overlooked signal molecule in physiology and pathology.CELL BIOLOGY INTERNATIONAL,47(2),1-13. |
| MLA | Wu, Yue,et al."Lactate: A pearl dropped in the ocean: An overlooked signal molecule in physiology and pathology".CELL BIOLOGY INTERNATIONAL 47.2(2023):1-13. |
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| Lactate a pearl drop（3313KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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