RCEES OpenIR  > 环境化学与生态毒理学国家重点实验室
Arsenic Levels and Speciation from Ingestion Exposures to Biomarkers in Shanxi, China: Implications for Human Health
Cui, Jinli; Shi, Jianbo; Jiang, Guibin; Jing, Chuanyong; Jing, CY
2013
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
Volume47Issue:10Pages:5419-5424
AbstractChronic exposure to arsenic (As) threatens human health. To systematically understand the health risks induced by As ingestion, we explored water and diet contributions to As exposure, and compared As in biomarkers and the arsenicosis in a geogenic As area in China. In this study, high percentages of water (77% of n = 131 total samples), vegetables (92%, n = 120), cereals (32%, n = 25), urine (70%, n = 99), nails (76%, n = 176), and hair (62%, n = 61) contained As higher than the acceptable levels. Dietary As contributed 92% of the average daily dose (ADD) when the water As concentration was less than 10 mu g/L, for which 5 out of 30 examined participants were diagnosed with arsenicosis symptoms. The distinct positive correlation between ADD and As concentrations in urine, nails, and hair suggests different applicability for these biomarkers. Methylated As as the predominant urinary As species confirms that the ingested inorganic As is methylated and is excreted through urine. In situ microdistribution and speciation analysis indicates that As is mainly associated with sulfur in nails and hair. Nails, rather than hair and urine, could be used as a proper biomarker for arsenicosis. High ADD from the environment and low excretion could result in As toxicity to humans.
Department环境化学与生态毒理学国家重点实验室
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Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/7496
Collection环境化学与生态毒理学国家重点实验室
Corresponding AuthorJing, CY
Recommended Citation
GB/T 7714
Cui, Jinli,Shi, Jianbo,Jiang, Guibin,et al. Arsenic Levels and Speciation from Ingestion Exposures to Biomarkers in Shanxi, China: Implications for Human Health[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2013,47(10):5419-5424.
APA Cui, Jinli,Shi, Jianbo,Jiang, Guibin,Jing, Chuanyong,&Jing, CY.(2013).Arsenic Levels and Speciation from Ingestion Exposures to Biomarkers in Shanxi, China: Implications for Human Health.ENVIRONMENTAL SCIENCE & TECHNOLOGY,47(10),5419-5424.
MLA Cui, Jinli,et al."Arsenic Levels and Speciation from Ingestion Exposures to Biomarkers in Shanxi, China: Implications for Human Health".ENVIRONMENTAL SCIENCE & TECHNOLOGY 47.10(2013):5419-5424.
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