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Structure-Activity Relationship Investigation on Reaction Mechanism between Chlorinated Quinoid Carcinogens and Clinically-Used Aldoxime Nerve-Agent Antidote under Physiological Condition 期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2021, 卷号: 34, 期号: 4, 页码: 1091-1100
Authors:  Xie, Lin-Na;  Huang, Chun-Hua;  Xu, Dan;  Qin, Li;  Li, Feng;  Shan, Guo-Qiang;  Liu, Zhi-Sheng;  Cao, Dong;  Geng, Fang-Lan;  Mao, Li;  Shao, Jie;  Sheng, Zhi-Guo;  Zhu, Ben-Zhan
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Concentration, spatial distribution, and health risk assessment of PFASs in serum of teenagers, tap water and soil near a Chinese fluorochemical industrial plant 期刊论文
ENVIRONMENT INTERNATIONAL, 2021, 卷号: 146, 页码: -
Authors:  Xie, Lin-Na;  Wang, Xiao-Chen;  Dong, Xiao-Jie;  Su, Li-Qin;  Zhu, Hui-Juan;  Wang, Cong;  Zhang, Dian-Ping;  Liu, Fang-Ying;  Hou, Sha-Sha;  Dong, Bing;  Shan, Guo-Qiang;  Zhang, Xu;  Zhu, Ying
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PFOA  Soil  Serum  Tap water  Health risk assessment  
Potent Oxidation of DNA by Haloquinoid Disinfection Byproducts to the More Mutagenic Imidazolone dlz via an Unprecedented Haloquinone-Enoxy Radical-Mediated Mechanism 期刊论文
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2020, 卷号: 54, 期号: 10, 页码: 6244-6253
Authors:  Shao, Jie;  Huang, Chun-Hua;  Shao, Bo;  Qin, Li;  Xu, Dan;  Li, Feng;  Qu, Na;  Xie, Lin-Na;  Kalyanaraman, Balaraman;  Zhu, Ben-Zhan
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Unexpected activation of N-alkyl hydroxamic acids to produce reactive N-centered free radicals and DNA damage by carcinogenic chlorinated quinones under normal physiological conditions 期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2020, 卷号: 146, 页码: 70-78
Authors:  Huang, Chun-Hua;  Xu, Dan;  Qin, Li;  Tang, Tian-Shu;  Shan, Guo-Qiang;  Xie, Lin-Na;  Li, Pei-Lin;  Mao, Li;  Shao, Jie;  Zhu, Ben-Zhan
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N-alkyl hydroxamic acids  N-centered radicals  Chlorinated quinones  Carbon-nitrogen bonding conjugate  DNA adducts  
An unexpected new pathway for nitroxide radical production via more reactve nitrogen-centered amidyl radical intermediate during detoxification of the carcinogenic halogenated quinones by N-alkyl hydroxamic acids 期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2020, 卷号: 146, 页码: 150-159
Authors:  Zhu, Ben-Zhan;  Xu, Dan;  Qin, Li;  Huang, Chun-Hua;  Xie, Lin-Na;  Mao, Li;  Shao, Jie;  Kalyanaraman, Balaraman
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N-centered amidyl radical  Nitroxide radical  Hydrogen-abstraction  Tetrachloroquinoid compounds  N-alkyl hydroxamic acids  
Molecular mechanism for the activation of the anti-tuberculosis drug isoniazid by Mn(III): First detection and unequivocal identification of the critical N-centered isoniazidyl radical and its exact location 期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2019, 卷号: 143, 页码: 232-239
Authors:  Qin, Li;  Huang, Chun-Hua;  Xu, Dan;  Xie, Lin-Na;  Shao, Jie;  Mao, Li;  Kalyanaraman, Balaraman;  Zhu, Ben-Zhan
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Isoniazid  Mn(III)(Acetate) 3  Isoniazidyl radical  Distal-nitrogen of the hydrazine group  Diisonicotinyl hydrazine  
Mechanism of unprecedented hydroxyl radical production and site-specific oxidative DNA damage by photoactivation of the classic arylhydroxamic acid carcinogens 期刊论文
CARCINOGENESIS, 2019, 卷号: 40, 期号: 9, 页码: 1153-1163
Authors:  Xu, Dan;  Huang, Chun-Hua;  Xie, Lin-Na;  Shao, Bo;  Mao, Li;  Shao, Jie;  Kalyanaraman, Balaraman;  Zhu, Ben-Zhan
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An unusual double radical homolysis mechanism for the unexpected activation of the aldoxime nerve-agent antidotes by polyhalogenated quinoid carcinogens under normal physiological conditions 期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2019, 卷号: 130, 页码: 1-7
Authors:  Xie, Lin-Na;  Shao, Jie;  Huang, Chun-Hua;  Li, Feng;  Xu, Dan;  Kalyanaraman, Balaraman;  Zhu, Ben-Zhan
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Radical homolysis mechanism  Iminyl radical  Tetrachloro-1, 4-benzoquinone (TCBQ)  Pyridinium aldoximes  Nerve-agent antidotes  Polyhalogenated quinoid carcinogens  
醛肟类神经性毒剂防治药物的新型解毒分子作用机制 期刊论文
中国科学:化学, 2018, 卷号: 48, 期号: 10, 页码: 1247-1259
Authors:  任福荣;  肖璇;  谢琳娜;  徐丹;  邵杰;  黄春华;  朱本占
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Beckmann裂解反应  吡啶盐醛肟  神经性毒剂防治药物  四氯-1,4-苯醌  解毒机理  
卤代芳烃化学发光的结构效应、分子机制及其应用 期刊论文
化学进展, 2017, 期号: 09, 页码: 930-942
Authors:  朱本占;  谢琳娜;  沈忱;  高慧颖;  朱丽雅;  毛莉
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卤代芳烃  高级氧化  化学发光  羟基自由基  卤代醌中间体  半醌自由基  结构-效应关系